منابع مشابه
CD8+ T Cells: GITR Matters
As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system. CD8(+) T cells are key players in the immunity against viruses and tumors, and GITR has been demonstrated to be an essential molecule for these cells to mount an immune response. The aim of this paper is to focus on GITR fu...
متن کاملThe role of GITR single‐positive cells in immune homeostasis
Dear Editor: In 2003, Uraushihara et al. demonstrated that CD4þCD25 GITRþ T cells express cytotoxic T lymphocyte–associated protein (CTLA-)4, are anergic, produce interleukin (IL)-10 and transforming growth factor (TGF)b, and exhibit regulatory activity [1]. In 2011, we demonstrated in human peripheral blood the existence of CD4þCD25lowGITRþ T lymphocytes isolated from a CD4þ population deplete...
متن کاملRegulatory T cells: context matters.
Regulatory T cells are important for ensuring that the immune system does not attack self and does not overreact to external antigens. Understanding how these cells develop and maintain stable function provides general insights into cellular differentiation in general, as well as new opportunities for therapeutic manipulation.
متن کاملSignaling through GITR, using agonist anti-GITR antibodies or GITR ligands abrogates the suppressive effects of Tregs (7,10) and enhances T cell responses (6,8,9,11). Administration of agonist anti-GITR antibodies promotes the activation of CTLs, and interferon
We attempted to enhance the antitumor effects of tumor lysate-pulsed dendritic cells by eliminating regulatory T cells. The combinatorial effects of dendritic cells and agonist anti-glucocorticoid-induced tumor necrosis factor receptor (anti-GITR) antibodies were investigated with respect to enhancement of the systemic immune response, elimination of regulatory T cells, and inhibition of tumor ...
متن کاملEngineered nanoparticles interacting with cells: size matters
With the rapid advancement of nanoscience and nanotechnology, detailed knowledge of interactions between engineered nanomaterials and cells, tissues and organisms has become increasingly important, especially in regard to possible hazards to human health. This review intends to give an overview of current research on nano-bio interactions, with a focus on the effects of NP size on their interac...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Scientific World Journal
سال: 2012
ISSN: 1537-744X
DOI: 10.1100/2012/308265